Robert M. Hazen | Geophysical Laboratory

Complexity

 

What factors promote the emergence of complex evolving systems, such as life? What is “complexity” and how can it be quantified? We have approached these questions by looking for general properties of all emergent systems (Hazen 2001; 2005; 2007) and by conducting computational experiments on the artificial life platform Avida (with Patrick Griffin). Our work amplifies the original studies of Szostak and coworkers, who proposed that “functional information” provides a measure of complexity in genetic polymers. The core idea is that “complexity” only has meaning in the context of “function” (Hazen et al., 2007; Hazen, 2007).

 

These ideas are summarized in the abstract of Hazen et al. (2007): “Complex emergent systems of many interacting components, including complex biological systems, have the potential to perform quantifiable functions. Accordingly, we define “functional information,”I(Ex), as a measure of system complexity. For a given system and function, (e.g., a folded RNA sequence that binds to GTP) and degree of function, Ex (e.g., the RNA-GTP binding energy):

 

I(Ex = -log2[F(Ex)],

 

where F(Ex) is the fraction of all possible configurations of the system that possess a degree of function ≥Ex. Functional information, which we illustrate with letter sequences, artificial life, and biopolymers, thus represents the probability that an arbitrary configuration of a system will achieve a specific function to a specified degree. In each case we observe evidence for several distinct solutions with different maximum degrees of function – features that lead to steps in plots of information versus degree of function.

Hazen, R.M. (2001) Emergence and the origin of life. In: G.Pályi (Editor) Fundamentals of Life. New York: Elsevier, pp.41-50.
Hazen, R. M. (2003) Factors that influence the emergence of complexity in prebiotic geochemical systems.  Astrobiology 2, 599. 
Hazen, R. M. (2005) Genesis: The Scientific Quest for Life’s Origin. Washington, DC: Joseph Henry Press, 339 p. (Softcover edition, 2007)
Hazen, R. M. (2007) Emergence and the experimental pursuit of the origin of life. In C. Bertka, editor, AAAS volume. New York: Cambridge University Press, in press.
Hazen, R. M., P. Griffin, J. M. Carothers and J. W. Szostak (2007) Functional information and the emergence of biocomplexity. Proceedings of the National Academy of Sciences USA 104, 8574-8581.
Hazen, R. M. (2007) The emergence of chemical complexity: An Introduction. In L. Zaikowski and J. M. Friedrich [editors], Chemical Evolution I: Chemical Change across Space and Time. American Chemical Society Symposium, pp.2-14.
Hazen, R. M. (2007) Emergence and the origin of life: Presentation, questions and responses. In C. Bertka, N. Roth and M. Shindell (Editors), Workshop Report: Philosophical, Ethical, and Theological Implications of Astrobiology. Washington, DC: American Association for the Advancement of Science. pp. 30-40.
Hazen, R. M. (2008) The emergence of patterning in life’s origin and evolution. International Journal of Developmental Biology, in press.

We have studied the functions of randomly-generated Avida genomes of varying lengths. In one set of computations we started with a highly functional 300-command genome and examined all possible single point mutations (300 x 25 alternate commands). We were surprised to find that the great majority of mutant genomes displayed no change in function, and a few mutant genomes had increased function.

Our tentative explanation for the discontinuities in plots of functional information versus degree of function is that for many complex systems there exist “islands of solutions” (e.g., functional Avida genomes). Here we show this phenomenon schematically as clusters of solutions projected onto an arbitrary sequence space. The different heights of relatively flat islands leads to gaps in function plots. 

These ideas are closely related to studies of pattern formation, as reviewed in Hazen (2008). From the abstract: “Three principles guide natural pattern formation in both biological and nonliving systems: (1) Patterns form from interactions of numerous individual particles, or “agents,” such as sand grains, molecules, cells or organisms. (2) Assemblages of agents can adopt combinatorially large numbers of different configurations. (3) Observed patterns emerge through the selection of highly functional configurations. These three principles apply to numerous natural processes, including the origin of life and its subsequent evolution. The formalism of “functional information,” which relates the information content of a complex system to its degree of function, provides a quantitative approach to modeling the origin and evolution of patterning in living and nonliving systems.”